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The Effect of E78 NP Concentration on the In Vitro Whole Blood Clotting Time
The Effect of E78 NP Concentration on the In Vitro Whole Blood Clotting Time
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Impedance aggregometry. (A) Negative control: E78 NPs (200 μg/mL) incubated...
Impedance aggregometry. (A) Negative control: E78 NPs (200 μg/mL) incubated with saline and challenged with 0.1 U/mL α-THR. Data suggest that in the presence of nanoparticles, but the absence of...
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Mean fluorescence intensity of PAC-1 binding after thrombin-induced platelet...
Mean fluorescence intensity of PAC-1 binding after thrombin-induced platelet activation in presence of increasing concentrations of E78 NPs and PEG-coated nanoparticles. There is a dose-dependent...
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Mean fluorescence intensity of PAC-1 binding to agonist-induced activated...
Mean fluorescence intensity of PAC-1 binding to agonist-induced activated platelets in presence and absence of E78 NPs (100 μg/mL). Data suggest that inhibition of agonist-induced platelet activation...
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Mean fluorescence intensity of PAC-1 binding to resting platelets (negative...
Mean fluorescence intensity of PAC-1 binding to resting platelets (negative control) and platelets in presence of thrombin (positive control) and nanoparticle formulations. Lack of significant...
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In vitro red blood cell (RBC) lysis. (A) Equal volume of Brij 78 (0–4 mM)...
In vitro red blood cell (RBC) lysis. (A) Equal volume of Brij 78 (0–4 mM) was added to the whole blood and incubated at 37°C; RBC lysis was determined spectrophotometrically (λ = 540 nm) based on...
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Biochemical and structural changes associated with platelet activation
Biochemical and structural changes associated with platelet activation
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Activation of platelets during cardiopulmonary bypass
Activation of platelets during cardiopulmonary bypass
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Risk Factors for Immunological Responses Against Injectable DDS
Risk Factors for Immunological Responses Against Injectable DDS
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Immunological Reactions Against Injectable DDS and their Clinical Consequences
Immunological Reactions Against Injectable DDS and their Clinical Consequences
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Relative Risk of Immunogenicity for Several Antigen Categories
Relative Risk of Immunogenicity for Several Antigen Categories
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Simplified schematic presentation of the interrelationship between the...
Simplified schematic presentation of the interrelationship between the immunological reactions discussed in the text. The dashed arrows represent possible, not yet confirmed pathways for platelet...
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DDS-mediated activation pathways of the complement system (adapted from...
DDS-mediated activation pathways of the complement system (adapted from (81)). For further details see text.
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Schematic illustration of the interaction of molecules (orange bullets,...
Schematic illustration of the interaction of molecules (orange bullets, which can be drugs, targeting ligands, or repeat units of a polymer) with B cell receptors (BCRs, surface immunoglobulins on B...
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